Cover Story

Medication Nation

Our increasing reliance on drugs—prescribed, over-the-counter, illegal, and ordered online like pizza—suggests we have a deeper problem

by Philip Alcabes

Articles

How Chemistry Became Biology

And how LUCA, Earth’s first living cell, became Lucas, my adorable grandnephew

by Priscilla Long

Awakenings

The advent of new religions in the 1800s led to fierce debates that persist today

by Susan Jacoby

My Newfoundland

The sensations of landing on the island long ago haunted a writer’s final memories

by Paul West

A Life in Letters

A decades-long correspondence with the Italian writer Arturo Vivante covered it all: hardship, love, and the endurance of art

by Merrill Joan Gerber

Where the Heart Is

A grandmother’s life in five moves, from Hitler’s Europe to the American Midwest

by Leslie Berlin

Departments

Editor's Note

Painkillers

Robert Wilson

Letters From …

Letter from the Aral Sea: All Dried Up

Jeffrey Tayler

Works in Progress

Climate Change in a New Light

Margaret Foster

Waves of Change

Simon Winchester

Spotted Opera

Our Editors

The Rap’s the Thing

Chloe Taft

Off the Charts

Brad Edmondson

Back to the Country

Charlotte Salley

Commonplace Book

Winter 2016

Anne Matthews

Book Reviews

A Model Marriage

Mary Beth Norton

Son of Gonzo

Scott Stossel

Riddles for the Afterlife

Sarah Ruden

Hail to the Chiefs

Michael Sherry

Taken to the Leader

Bruce Cumings

Hot Rocks

Sarah Zielinski

Speaking in Tongues

Michael Upchurch

Back Talk

Cellspeak

Ralph Keyes

Fiction

Real Papa

Onyinye Ihezukwu

Poetry

Appetites

The poetry of Sandra M. Gilbert

Langdon Hammer

Four Poems

Delicious poems from the paintings of four masters

Sandra M. Gilbert

Arts

The Phaedra Syndrome

Desire, denial, and the making of compelling TV

André Aciman

Vermeer and the Art of Solitude

Some works are not meant to be blockbusters

Sudip Bose

Jacob A. Riis: The Other Half

A retrospective at the Museum of the City of New York

Our Editors

Tuning Up

Evolution by Other Means

Natural selection isn’t the whole story of human development

Ian Tattersall